(R)-2-(Hydroxymethyl)morpholine-4-carboxylic acid tert-butyl ester
CAS NO：135065-71-3
(R)-N-Boc-2-hydroxymethylpiperidine serves as an intermediate in organic synthesis and chiral pharmaceutical intermediates, primarily used for the synthesis of chiral compounds in laboratory research and chemical pharmaceutical development processes.
Through template screening, inhibitors for Checkpoint kinase 1 have been identified to suppress primary tumor growth.
It is a new intermediate used for the treatment of lung cancer.
Mass production has been applied to this product.
Contact: Ms Wang
Mobile: 13564545227
Products targeting Checkpoint
BML-277
BML-277 is a novel and efficient Chk2 inhibitor, with an IC50 of 15 nM.
CHIR-124
CHIR-124 is a novel and effective Chk1 inhibitor, with an IC50 of 0.3 nM, exhibiting 2000-fold higher selectivity for Chk1 over Chk2 and 500 to 5,000-fold lower activity towards CDK2/4 and Cdc2.
PF-477736
PF-477736 is an effective and selective ATP-competitive Chk1 inhibitor, with a Ki of 0.49 nM, also inhibiting VEGFR2, Aurora-A, FGFR3, Flt3, Fms (CSF1R), Ret, and Yes. It displays approximately 100-fold higher selectivity for Chk1 over Chk2.
AZD7762
AZD7762 is an effective and selective Chk1 inhibitor, with an IC50 of 5 nM, also equally effective on Chk2, with slightly weaker effects on CAM, Yes, Fyn, Lyn, Hck, and Lck.
Prexasertib
Prexasertib (LY2606368) is a selective, ATP-competitive second-generation cell cycle checkpoint kinase (CHK1) inhibitor, with a Ki of 0.9 nM and an IC50 of < 1 nM. Prexasertib inhibits CHK2 (IC50=8 nM) and RSK1 (IC50=9 nM).
GDC-0575 dihydrochionee
GDC-0575 dihydrochloride (ARRY-575 dihydrochloride) is a selective and orally available CHK1 inhibitor, with an IC50 of 1.2 nM, demonstrating anti-tumor activity.
SAR-020106
SAR-020106 hydrochloride is an ATP-competitive and highly selective CHK1 inhibitor, with an IC50 of 13.3 nM and good selectivity for CHK2. SAR-020106 enhances the cytotoxicity of Gemcitabine and SN38 in several colon tumor cell lines in a p53-dependent manner, enhancing anti-tumor activity.
GDC-0575(ARRY-575）
GDC-0575 (ARRY-575, RG7741) is an effective, orally active CHK1-selective inhibitor, with an IC50 of 1.2 nM.
CCT245737
CCT245737 is an effective, selective, and orally active checkpoint kinase 1 (CHK1) inhibitor, with IC50 values of 1.3 nM for CHK1, 2440 nM for CHK2, and 30nM for G2 checkpoint abrogation.
PD0166285
PD0166285 is an effective Wee1 and Chk1 inhibitor, with IC50 values of 24 nM and 72 nM, respectively.
Prexasertib dihydrochioride
Prexasertib dihydrochloride (LY2606368 HCl) is an effective, ATP-competitive, selective CHK1 inhibitor, with IC50 values of < 1 nM for CHK1 and 8 nM for CHK2.
lpilimumab
Ipilimumab (MDX-010.BMS-734015) is an immune-modulating monoclonal antibody targeting the cell surface antigen CTLA-4, serving as an immune checkpoint inhibitor.
CCT241533 hydrochloride
CCT241533 hydrochloride is a highly active threonine/serine Chk2 inhibitor, with an IC50 of 3 nM.
AZD7762（hdrochionde）
AZD7762 hydrochloride is an effective, selective CHK1 inhibitor, with an IC50 of 5 nM, similar inhibition towards Chk2, but weaker inhibition towards CAM, Yes, Fyn, Lyn, Hck, and Lck.
Rabusertib （LY2603618)
LY2603618 is a selective CHK1 inhibitor, with potential anti-tumor activity.
PF-477736
PF-477736 is an effective and selective ATP-competitive Chk1 inhibitor, with a Ki of 0.49 nM, also inhibiting VEGFR2, Aurora-A, FGFR3, Flt3, Fms (CSF1R), Ret, and Yes. It displays approximately 100-fold higher selectivity for Chk1 over Chk2.
AZD7762
AZD7762 is an effective and selective Chk1 inhibitor, with an IC50 of 5 nM, also equally effective on Chk2, with slightly weaker effects on CAM, Yes, Fyn, Lyn, Hck, and Lck.
CHIR-124
CHIR-124 is a novel and effective Chk1 inhibitor, with an IC50 of 0.3 nM, exhibiting 2000-fold higher selectivity for Chk1 over Chk2 and 500 to 5,000-fold lower activity towards CDK2/4 and Cdc2.
BML-277
BML-277 is a novel and efficient Chk2 inhibitor, with an IC50 of 15 nM.
GDC-0425
GDC-0425 (RG-7602) is an effective, orally available, highly selective ChK1 inhibitor, used in various malignant tumor research.
GNE-900
GNE-900 is an ATP-competitive, selective, and orally active ChK1 inhibitor, with IC50 values of 0.0011 and 1.5μM for ChK1 and ChK2, respectively. GNE-900 abolishes the G2-M checkpoint, enhances DNA damage, induces apoptosis, and demonstrates anti-tumor activity when administered with gemcitabine.
G0C0575 hydrochioride
GDC0575 (ARRY-575) hydrochloride is a highly selective, orally active CHK1 inhibitor (IC50=1.2nM), used in colon inflammation-related cancer and colon research.
VER-00158411
VER-00158411 is a CHK1 and CHK2 inhibitor, with IC50 values of 4.4 nM and 4.5 nM, respectively.
Monalzumab
Monalizumab is a first-in-class immune checkpoint inhibitor targeting the natural killer cell group 2A (NKG2A), used in head and neck squamous cell carcinoma (HNSCC) research.
WAY-239320
Prexaserto dmesylate
Prexasertib dimesylate (LY2806368 dimesylate) is a selective, ATP-competitive second-generation cell cycle checkpoint kinase 1 (CHK1) inhibitor, with a Ki of 0.9nM and an IC50 of <1mM.
CCT244747
CCT244747 is an effective, orally available, highly selective CHK1 inhibitor, with an IC50 of 7.7 nM; it abolishes the G2 checkpoint with an IC50 of 29 nM.
SCH 900776
SCH 900776 (MK-8776) is a selective Chk1 inhibitor, with an IC50 of 3 nM, exhibiting 500-fold higher selectivity for Chk1 over Chk2.
BIBR1532
BIBR 1532 is an effective, selective, and non-competitive telomerase inhibitor, with an IC50 of 100 nM, also acting through ATM/CHK1 pathway inhibition.
CHK1-IN-7
CHK1-IN-7 is an effective human CHK1 inhibitor.
Chk2-IN-1
Chk2-IN-1 (compound 1) is an effective and selective checkpoint kinase 2 (Chk2) inhibitor, with IC50 values of 13.5 nM and 220.4 nM for Chk2 and Chk1, respectively, inducing strong ATM-dependent Chk2-mediated radiation protection.
MU380
MU380 is a potent, selective CHK1 inhibitor, inducing apoptosis and demonstrating anti-cancer activity.
